Shandong Mengxi: Nws lub luag haujlwm hauv magnetic resonance imaging

Gadolinium oxide hmoovyog siv los ua tus neeg sawv cev sib txawv hauv kev sib nqus resonance imaging (MRI), feem ntau los txhim kho qhov sib txawv ntawm cov khoom sib txawv los ntawm nws lub cev thiab tshuaj lom neeg. Lub gadolinium ions nyob rau hauv gadolinium oxide tuaj yeem cuam tshuam qhov sib nqus susceptibility ntawm dej molecules nyob rau hauv ib puag ncig cov ntaub so ntswg. Thaum lub sij hawm MRI, dej molecules yog lub ntsiab imaging qhov chaw, thiab cov kev hloov nyob rau hauv lawv magnetic susceptibility ncaj qha cuam tshuam qhov kev siv thiab sib piv ntawm imaging signals.Gadolinium oxide hmoovhloov qhov sib nqus susceptibility ntawm dej molecules, ua rau cov duab sib txawv ntawm cov kab mob thiab cov ntaub so ntswg ib txwm tseem ceeb, yog li txhim kho qhov sib piv ntawm cov duab. Gadolinium oxide feem ntau chelates nrog lwm cov molecules (xws li DTPA, DOTA, thiab lwm yam) los tsim cov complexes ruaj khov, uas muaj toxicity tsawg hauv vivo thiab muaj peev xwm tswj tau lub sijhawm ntev. Thaum cov complexes no tau siv los ua MRI sib piv cov neeg ua haujlwm, lawv tuaj yeem nrhiav tau cov ntaub so ntswg kom raug, txhim kho cov duab raug thiab qhov sib txawv. Piv nrog rau cov tsoos gadolinium-based chelates, nano gadolinium oxide hais muaj tsawg dua kev pheej hmoo ntawm gadolinium ion to, loj dua qhov chaw, thiab ntau dua so. Lub siab so tus nqi txhais tau hais tias lub teeb liab ua kom muaj zog, uas pab txhim kho qhov sib piv ntawm MRI cov duab. Tsis tas li ntawd, lub hom phiaj tsim ntawm nanoparticles tuaj yeem ua rau lawv mus cuag cov ntaub so ntswg kom raug ntau dua, txhim kho kev ua haujlwm ntxiv.
Ib hom tshiab ntawm kev sib piv tus neeg sawv cev, chitosan cross-linked folate-coated gadolinium oxide, yog siv rau cov qog-targeted magnetic resonance imaging. Tus neeg sawv cev tshiab no sib xyaw ua ke biocompatibility ntawm chitosan, qog-targeting zog ntawm folate, thiab lub siab so ntawm gadolinium oxide. Nws tuaj yeem txhim kho qhov sib piv ntawm MRI cov duab thaum ua tiav cov qog nqaij hlav hauv zos. Tus neeg saib xyuas qhov sib txawv no muaj cov ntawv thov dav dav hauv kev kuaj mob qog.
Los ntawm qhov no, nws tuaj yeem pom tiasgadolinium oxide hmoovplays lub luag haujlwm tseem ceeb hauv kev sib nqus resonance imaging. Nyob rau tib lub sijhawm, peb kuj muaj cov neeg siv khoom sib txuas uas yog cov chaw tshawb fawb tshuaj lom neeg uas tshwj xeeb tuaj rau peb los yuav gadolinium oxide; Qhov laj thawj yog vim li cas koj xaiv peb yog vim peb cov khoom yog qhov kev xaiv zoo tshaj plaws ntawm purity thiab cov khoom muag. Tib lub sijhawm, peb muaj ib pab neeg tshaj lij los pab koj thiab muab koj cov kev paub zoo tshaj plaws rau cov neeg siv khoom!